Phenotypes associated with this allele

• Allele Symbol: Gimap3^tm1.1Yout
• Allele Name: targeted mutation 1.1, Yousuke Takahama
• Allele ID: MGI:6280701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gimap3^tm1.1Yout/Gimap3^tm1.1Yout	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:6286503

Genotype
MGI:6286503

hm1

• Allelic Composition: Gimap3^tm1.1Yout/Gimap3^tm1.1Yout
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:209926 )

N • normal thymocyte cellularity

decreased thymocyte number ( J:209926 )

• decrease in CD4- CD8- , CD4+ CD8+, CD4+, and CD8+ thymocyte numbers in competitive chimeric bone marrow transplantation model (equal number of mutant and wild-type BM cells transplanted into nude mouse)

hematopoietic system

hematopoietic system phenotype ( J:209926 )

N • normal cellularity of B cells and NK1.1+ CD3-, NK1.1+ CD3+, CD4+, and CD8+ T cells in spleen and lymph nodes

N • expression of CD44 and CD62L in CD4+ T cells and CD8+ T cells in spleen

decreased T cell number ( J:209926 )

• decrease in CD4+ and CD8+ T cell numbers in spleen in competitive chimeric bone marrow transplantation model (equal number of mutant and wild-type BM cells transplanted into nude mouse)

decreased thymocyte number ( J:209926 )

• decrease in CD4- CD8- , CD4+ CD8+, CD4+, and CD8+ thymocyte numbers in competitive chimeric bone marrow transplantation model (equal number of mutant and wild-type BM cells transplanted into nude mouse)

immune system

decreased T cell number ( J:209926 )

• decrease in CD4+ and CD8+ T cell numbers in spleen in competitive chimeric bone marrow transplantation model (equal number of mutant and wild-type BM cells transplanted into nude mouse)

decreased thymocyte number ( J:209926 )

• decrease in CD4- CD8- , CD4+ CD8+, CD4+, and CD8+ thymocyte numbers in competitive chimeric bone marrow transplantation model (equal number of mutant and wild-type BM cells transplanted into nude mouse)