All Phenotypes Clptm1l<tm1d(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Clptm1l^{tm1d(EUCOMM)Wtsi}
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:6281109

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l^{tm1d(EUCOMM)Wtsi}	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N	MGI:6281127
ht2	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l⁺	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N	MGI:6281137
cx3	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l^{tm1d(EUCOMM)Wtsi} Prdm1^tm1Nutt/Prdm1⁺	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N	MGI:6281129

Allelic Composition	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l^{tm1d(EUCOMM)Wtsi}
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
Cell Lines	EPD0460_2_E07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1l^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Clptm1l mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:265892 )

• only 5 of 37 pups born survive past postnatal day 2

neonatal lethality, incomplete penetrance ( J:265892 )

• fewer than 15% of the born pups survive past postnatal day 2

• however, pups that survive the neonatal period are healthy, fertile and indistinguishable from wild-type controls

prenatal lethality, incomplete penetrance ( J:265892 )

• mice are born at a significantly lower than expected frequency from heterozygous mating pairs

immune system

immune system phenotype ( J:265892 )

N	• surviving mice show no differences in the development, maturation and differentiation of B-lymphocytes into antibody secreting cells or in immunoglobulin class-switch recombination relative to wild-type controls

Allelic Composition	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l⁺
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
Cell Lines	EPD0460_2_E07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1l^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Clptm1l mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:265892 )

• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells

hematopoietic system

abnormal class switch recombination ( J:265892 )

• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells

Allelic Composition	Clptm1l^{tm1d(EUCOMM)Wtsi}/Clptm1l^{tm1d(EUCOMM)Wtsi} Prdm1^tm1Nutt/Prdm1⁺
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N
Cell Lines	EPD0460_2_E07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1l^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Clptm1l mutation (34 available)
Prdm1^tm1Nutt mutation (1 available); any Prdm1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:265892 )

N	• mice show no significant differences in the frequency of bone marrow plasma cells, splenic plasma cells and splenic plasmablasts, or in the serum concentrations of IgM, IgG1, IgG2b, IgG2c, IgG3 or IgA relative to wild-type controls

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