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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clptm1ltm1d(EUCOMM)Wtsi
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:6281109
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clptm1ltm1d(EUCOMM)Wtsi/Clptm1ltm1d(EUCOMM)Wtsi involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N MGI:6281127
ht2
 		Clptm1ltm1d(EUCOMM)Wtsi/Clptm1l+ involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N MGI:6281137
cx3
 		Clptm1ltm1d(EUCOMM)Wtsi/Clptm1ltm1d(EUCOMM)Wtsi
Prdm1tm1Nutt/Prdm1+ 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N MGI:6281129


Genotype
MGI:6281127
hm1
Allelic
Composition		 Clptm1ltm1d(EUCOMM)Wtsi/Clptm1ltm1d(EUCOMM)Wtsi
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
Cell Lines EPD0460_2_E07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation (0 available); any Clptm1l mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:265892 )
• only 5 of 37 pups born survive past postnatal day 2
neonatal lethality, incomplete penetrance ( J:265892 )
• fewer than 15% of the born pups survive past postnatal day 2
• however, pups that survive the neonatal period are healthy, fertile and indistinguishable from wild-type controls
prenatal lethality, incomplete penetrance ( J:265892 )
• mice are born at a significantly lower than expected frequency from heterozygous mating pairs

immune system
immune system phenotype ( J:265892 )
N
• surviving mice show no differences in the development, maturation and differentiation of B-lymphocytes into antibody secreting cells or in immunoglobulin class-switch recombination relative to wild-type controls




Genotype
MGI:6281137
ht2
Allelic
Composition		 Clptm1ltm1d(EUCOMM)Wtsi/Clptm1l+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
Cell Lines EPD0460_2_E07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation (0 available); any Clptm1l mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:265892 )
• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells

hematopoietic system
abnormal class switch recombination ( J:265892 )
• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells




Genotype
MGI:6281129
cx3
Allelic
Composition		 Clptm1ltm1d(EUCOMM)Wtsi/Clptm1ltm1d(EUCOMM)Wtsi
Prdm1tm1Nutt/Prdm1+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N
Cell Lines EPD0460_2_E07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation (0 available); any Clptm1l mutation (34 available)
Prdm1tm1Nutt mutation (1 available); any Prdm1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:265892 )
N
• mice show no significant differences in the frequency of bone marrow plasma cells, splenic plasma cells and splenic plasmablasts, or in the serum concentrations of IgM, IgG1, IgG2b, IgG2c, IgG3 or IgA relative to wild-type controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory