Phenotypes associated with this allele

• Allele Symbol: Prmt7^tm1.2Rchd
• Allele Name: targeted mutation 1.2, Stephane Richard
• Allele ID: MGI:6281578
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prmt7^tm1.2Rchd/Prmt7^tm1.2Rchd	involves: 129S4/SvJaeSor * FVB/N	MGI:6314344

Genotype
MGI:6314344

hm1

• Allelic Composition: Prmt7^tm1.2Rchd/Prmt7^tm1.2Rchd
• Genetic Background: involves: 129S4/SvJaeSor * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myoblast differentiation ( J:271361 )

• impaired differentiation of satellite cells from isolated single muscle fibers of the extensor digitorum longus

decreased skeletal muscle weight ( J:271361 )

• at 8 months of age

decreased satellite cell number ( J:271361 )

• slightly in untreated mice and further in cardiotoxin-treated mice

abnormal muscle physiology ( J:271361 )

• satellite cells isolated from 8 month mice exhibit premature senescence unlike wild-type cells

impaired skeletal muscle regeneration ( J:271361 )

• with a decrease in centrally nucleated fibers after cardiotoxin-injured

growth/size/body

decreased birth weight ( J:271361 )

• in female and male mice

decreased body weight ( J:271361 )

• in female and male mice at 3 months of age

• however, weight at 8 months are normal

homeostasis/metabolism

abnormal response to injury ( J:271361 )

• cardiotoxin-injured tibialis anterior muscles isolated from 8 month mice exhibit premature senescence unlike wild-type cells

adipose tissue

increased epididymal fat pad weight ( J:271361 )

• at 8 months of age

• however, retroperitoneal and subcutaneous fat depots are normal

cellular

abnormal myoblast differentiation ( J:271361 )

• impaired differentiation of satellite cells from isolated single muscle fibers of the extensor digitorum longus

early cellular replicative senescence ( J:271361 )

• satellite cells or cardiotoxin-injured tibialis anterior muscles isolated from 8 month mice exhibit premature senescence unlike wild-type cells