All Phenotypes Igf2bp2<tm1Mini> MGI Mouse

extended life span ( J:271356 )

• in female and male mice

decreased lean body mass ( J:271356 )

• whether fed normal chow or a high-fat diet, mice exhibit reduced lean mass gain beginning at 8 weeks

decreased body weight ( J:271356 )

• at 30 weeks when fed normal chow

• exaggerated when mice are fed a high-fat diet

decreased body length ( J:271356 )

• at 14 weeks in male mice fed normal chow

increased susceptibility to diet-induced obesity ( J:271356 )

• in mice fed a high-fat diet

increased liver weight ( J:271356 )

• in female mice

homeostasis/metabolism phenotype ( J:271356 )

N	• whether fed normal chow or a high-fat diet, mice exhibit normal serum IGF1 and IGFBP3 levels

increased susceptibility to diet-induced obesity ( J:271356 )

• in mice fed a high-fat diet

decreased susceptibility to induced hypothermia ( J:271356 )

• when fed normal chow, cold-exposed mice exhibit lesser decrease in body temperature compared with wild-type mice

decreased circulating glucose level ( J:271356 )

• fed or fasting at 4 weeks of age

decreased fasting circulating glucose level ( J:271356 )

• at 4 weeks of age in mice fed normal chow

• in mice fed a high-fat diet

decreased circulating insulin level ( J:271356 )

• in mice when fed a high-fat diet

decreased circulating cholesterol level ( J:271356 )

• whether fed normal chow or a high-fat diet

decreased circulating free fatty acids level ( J:271356 )

• whether fed normal chow or a high-fat diet

decreased circulating triglyceride level ( J:271356 )

• whether fed normal chow or a high-fat diet

increased energy expenditure ( J:271356 )

• however, respiratory exchange ratio and absolute energy expenditure are normal

improved glucose tolerance ( J:271356 )

• at 12 to 14 weeks of age in wild-type mice when fed a high-fat diet

increased insulin sensitivity ( J:271356 )

• at 14 weeks of age in wild-type mice when fed a high-fat diet

abnormal liver triglyceride level ( J:271356 )

• mice fed a high-fat diet fail to exhibit an increase in liver triglyceride levels compared with wild-type mice

decreased subcutaneous adipose tissue amount ( J:271356 )

• in male mice

decreased white adipose tissue amount ( J:271356 )

• visceral white adipose tissue in female mice

decreased total body fat amount ( J:271356 )

• when fed normal chow (beginning at 12 weeks) and more so when fed a high-fat diet (beginning at 8 weeks) due to fewer adult adipocytes

whitened brown adipose tissue morphology ( J:271356 )

• paler than in wild-type mice when fed a high-fat diet after 8 weeks

• however, interscapular brown adipose tissue is normal in mice fed normal chow

decreased white fat cell number ( J:271356 )

abnormal brown adipose tissue thermogenesis ( J:271356 )

• 2-fold greater uncoupled oxygen consumption in vitro compared with wild-type cells

increased liver weight ( J:271356 )

• in female mice

abnormal liver triglyceride level ( J:271356 )

• mice fed a high-fat diet fail to exhibit an increase in liver triglyceride levels compared with wild-type mice

decreased susceptibility to diet-induced hepatic steatosis ( J:271356 )

• in mice fed a high-fat diet

decreased tumor incidence ( J:271356 )

• at necropsy (in mice between 845 and 850 days age) no malignancies are detected in 6 mice compared to 4 out of 6 wild-type mice

behavior/neurological phenotype ( J:271356 )

N	• whether fed normal chow or a high-fat diet, mice exhibit normal food intake and physical activity

decreased subcutaneous adipose tissue amount ( J:271356 )

• in male mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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