Phenotypes associated with this allele

• Allele Symbol: Betalinc1^tm1Suss
• Allele Name: targeted mutation 1, Lori Sussel
• Allele ID: MGI:6281721
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Betalinc1^tm1Suss/Betalinc1^tm1Suss	involves: 129 * C57BL/6	MGI:6282049

Genotype
MGI:6282049

hm1

• Allelic Composition: Betalinc1^tm1Suss/Betalinc1^tm1Suss
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic alpha cell number ( J:231585 )

• at E15.5

decreased pancreatic beta cell number ( J:231585 )

• at E15.5 and P2

increased pancreatic delta cell number ( J:231585 )

• 3-fold at E15.5

• at P2

decreased pancreatic epsilon cell number ( J:231585 )

• at E15.5

abnormal endocrine pancreas development ( J:231585 )

• development of endocrine cells is disrupted with reduced Neurog3 expression

• however, proliferation and apoptosis rates are normal

homeostasis/metabolism

increased circulating insulin level ( J:231585 )

• under fasting condition

impaired glucose tolerance ( J:231585 )

• mildly with failure to increase circulating insulin levels upon glucose stimulation

insulin resistance ( J:231585 )

• mildly