craniofacial
• reduced width of medionasal process in E11.5 embryos
• reduced number of mitotic cells in medionasal prominence in E11.5 embryos
• normal apoptosis
|
• in 4/121 E14-15 embryos
|
cleft palate
(
J:212391
)
• no palatal clefts in pups
• in 4/121 E14-15 embryos
|
• abnormal nasal-frontal bone suture
|
short snout
(
J:212391
)
• shorter nasal, frontal and parietal bone length at age 3 weeks
• normal parietal bone length at age 5 weeks
|
digestive/alimentary system
cleft palate
(
J:212391
)
• in 4/121 E14-15 embryos
• no palatal clefts in pups
|
embryo
N |
• born at normal Mendelian ratios
|
growth/size/body
• in 4/121 E14-15 embryos
|
cleft palate
(
J:212391
)
• in 4/121 E14-15 embryos
• no palatal clefts in pups
|
• abnormal nasal-frontal bone suture
|
short snout
(
J:212391
)
• shorter nasal, frontal and parietal bone length at age 3 weeks
• normal parietal bone length at age 5 weeks
|
mortality/aging
• some mice die before weaning
|