All Phenotypes Pierce2<em1(IMPC)H> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pierce2^em1(IMPC)H
endonuclease-mediated mutation 1, Harwell
MGI:6283399

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H	C57BL/6N-Pierce2^em1(IMPC)H/H	MGI:6480411
hm2	Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H	involves: C57BL/6N	MGI:6849739
cx3	Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi} Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H	involves: C57BL/6N	MGI:6849740
cx4	Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi} Pierce2^em1(IMPC)H/Pierce2⁺	involves: C57BL/6N	MGI:6849741

Allelic Composition	Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H
Genetic Background	C57BL/6N-Pierce2^em1(IMPC)H/H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce2^em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)

Data Sources

IMPC Data for Pierce2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

prolonged QRS complex duration ( J:211773 )

IMPC - HAR

shortened QT interval ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating calcium level ( J:211773 )

IMPC - HAR

Allelic Composition	Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce2^em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal motile primary cilium physiology ( J:316131 )

• reduced beating frequency without alteration in left-right axis

• however, tracheal cilia beating frequency is normal

cellular

abnormal motile primary cilium physiology ( J:316131 )

• reduced beating frequency without alteration in left-right axis

• however, tracheal cilia beating frequency is normal

Allelic Composition	Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi} Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce1^{tm2b(EUCOMM)Wtsi} mutation (2 available); any Pierce1 mutation (28 available)
Pierce2^em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:316131 )

• few surviving mice die by P20

prenatal lethality, incomplete penetrance ( J:316131 )

• fewer than expected mice are born

growth/size/body

situs ambiguus ( J:316131 )

• in some mice

situs inversus ( J:316131 )

• in most mice

nervous system

hydrocephaly ( J:316131 )

Allelic Composition	Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi} Pierce2^em1(IMPC)H/Pierce2⁺
Genetic Background	involves: C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

situs ambiguus ( J:316131 )

• in some mice

situs inversus ( J:316131 )

• in some mice

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