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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pierce2em1(IMPC)H
endonuclease-mediated mutation 1, Harwell
MGI:6283399
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H C57BL/6N-Pierce2em1(IMPC)H/H MGI:6480411
hm2
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H involves: C57BL/6N MGI:6849739
cx3
Pierce1tm2b(EUCOMM)Wtsi/Pierce1tm2b(EUCOMM)Wtsi
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H
involves: C57BL/6N MGI:6849740
cx4
Pierce1tm2b(EUCOMM)Wtsi/Pierce1tm2b(EUCOMM)Wtsi
Pierce2em1(IMPC)H/Pierce2+
involves: C57BL/6N MGI:6849741


Genotype
MGI:6480411
hm1
Allelic
Composition
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H
Genetic
Background
C57BL/6N-Pierce2em1(IMPC)H/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce2em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system

homeostasis/metabolism




Genotype
MGI:6849739
hm2
Allelic
Composition
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce2em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• reduced beating frequency without alteration in left-right axis
• however, tracheal cilia beating frequency is normal

cellular
• reduced beating frequency without alteration in left-right axis
• however, tracheal cilia beating frequency is normal




Genotype
MGI:6849740
cx3
Allelic
Composition
Pierce1tm2b(EUCOMM)Wtsi/Pierce1tm2b(EUCOMM)Wtsi
Pierce2em1(IMPC)H/Pierce2em1(IMPC)H
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce1tm2b(EUCOMM)Wtsi mutation (2 available); any Pierce1 mutation (28 available)
Pierce2em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few surviving mice die by P20
• fewer than expected mice are born

growth/size/body
• in some mice
• in most mice

nervous system




Genotype
MGI:6849741
cx4
Allelic
Composition
Pierce1tm2b(EUCOMM)Wtsi/Pierce1tm2b(EUCOMM)Wtsi
Pierce2em1(IMPC)H/Pierce2+
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pierce1tm2b(EUCOMM)Wtsi mutation (2 available); any Pierce1 mutation (28 available)
Pierce2em1(IMPC)H mutation (1 available); any Pierce2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in some mice
• in some mice





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory