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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf12M3Btlr
mutation 3, Bruce Beutler
MGI:6283517
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf12M3Btlr/Tcf12M3Btlr C57BL/6J-Tcf12M3Btlr MGI:6283521


Genotype
MGI:6283521
hm1
Allelic
Composition		 Tcf12M3Btlr/Tcf12M3Btlr
Genetic
Background		 C57BL/6J-Tcf12M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12M3Btlr mutation (0 available); any Tcf12 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:271971 )
• reduced frequencies of B cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:271971 )
• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:271971 )
• increased frequencies of CD8+ T cells in the peripheral blood

hematopoietic system
decreased B cell number ( J:271971 )
• reduced frequencies of B cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:271971 )
• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:271971 )
• increased frequencies of CD8+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory