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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkb1M5Btlr
mutation 5, Bruce Beutler
MGI:6283996
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkb1M5Btlr/Nfkb1M5Btlr C57BL/6J-Nfkb1M5Btlr MGI:6283998


Genotype
MGI:6283998
hm1
Allelic
Composition		 Nfkb1M5Btlr/Nfkb1M5Btlr
Genetic
Background		 C57BL/6J-Nfkb1M5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1M5Btlr mutation (0 available); any Nfkb1 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:272117 )
• reduced frequencies of B1a cells in B1 cells in the peripheral blood
decreased IgE level ( J:272117 )
• reduced circulating levels of IgE
decreased interleukin-1 beta secretion ( J:272117 )
• reduced secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment (NLRP3 inflammasome response) and in response to priming with flagellin (NLRC4 inflammasome response)

hematopoietic system
decreased B-1a cell number ( J:272117 )
• reduced frequencies of B1a cells in B1 cells in the peripheral blood
decreased IgE level ( J:272117 )
• reduced circulating levels of IgE




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory