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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3m12Btlr
mutation 12, Bruce Beutler
MGI:6284017
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3m12Btlr/Nlrp3m12Btlr C57BL/6J-Nlrp3m12Btlr MGI:6284019


Genotype
MGI:6284019
hm1
Allelic
Composition		 Nlrp3m12Btlr/Nlrp3m12Btlr
Genetic
Background		 C57BL/6J-Nlrp3m12Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3m12Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:272150 )
• reduced secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment (NLRP3 inflammasome response)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory