Phenotypes associated with this allele

• Allele Symbol: Orc2^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6284488
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orc2^em1(IMPC)J/Orc2^em1(IMPC)J	C57BL/6NJ-Orc2^em1(IMPC)J/Mmjax	MGI:6480538
ht2	Orc2^em1(IMPC)J/Orc2^+	C57BL/6NJ-Orc2^em1(IMPC)J/Mmjax	MGI:7317032

Genotype
MGI:6480538

hm1

• Allelic Composition: Orc2^em1(IMPC)J/Orc2^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Orc2^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Orc2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Orc2^em1(IMPC)J/Orc2^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form in vitro outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although blastocysts are present in approximate Mendelian ratios at E3.5 (42% versus expected 25%, n=38), no homozygous embryos are recovered at E7.5; however, excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form outgrowths after 3 days in culture

Genotype
MGI:7317032

ht2

• Allelic Composition: Orc2^em1(IMPC)J/Orc2⁺
• Genetic Background: C57BL/6NJ-Orc2^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Orc2

behavior/neurological

limb grasping ( J:211773 )

IMPC - JAX