All Phenotypes Tg(TYRO3)1Sapc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(TYRO3)1Sapc
transgene insertion 1, Sabine Cordes
MGI:6284560

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	anx/anx Tg(TYRO3)1Sapc/? Tyro3^m1/Tyro3^m1	involves: C3HeB/FeJLe * C57BL/6J	MGI:6287398

Allelic Composition	anx/anx Tg(TYRO3)1Sapc/? Tyro3^m1/Tyro3^m1
Genetic Background	involves: C3HeB/FeJLe * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
anx mutation (1 available); any anx mutation (1 available)
Tg(TYRO3)1Sapc mutation (0 available)
Tyro3^m1 mutation (4 available); any Tyro3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body weight ( J:241666 )

• relative to anx homozygotes lacking the TYRO3 human wildtype transgene, these mice show a partial rescue of the anorexia phenotype with the body weight at 21 days of age 92.8% increased on average

mortality/aging

abnormal survival ( J:241666 )

• wildtype human TYRO3 partially rescues the anx homozygous phenotype, with anx homozygotes still dying prematurely, but surviving past 35 days of age and showing no or only mild behavioural phentoypes of headweaving, ataxia, or tremors

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