Phenotypes associated with this allele

• Allele Symbol: Tg^m4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:6285492
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tg^m4Btlr/Tg^m4Btlr	C57BL/6J-Tg^m4Btlr	MGI:6285494

Genotype
MGI:6285494

hm1

• Allelic Composition: Tg^m4Btlr/Tg^m4Btlr
• Genetic Background: C57BL/6J-Tg^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1a cell number ( J:272522 )

• increased frequencies of B1a cells in the peripheral blood

decreased B cell number ( J:272522 )

• reduced frequencies of IgM+ B cells in the peripheral blood

decreased B-2 B cell number ( J:272522 )

• reduced frequencies of B2 cells in the peripheral blood

increased alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

increased macrophage cell number ( J:272522 )

• increased frequencies of macrophages in the peripheral blood

increased IgE level ( J:272522 )

• increased total IgE levels in the serum

growth/size/body

decreased body weight ( J:272522 )

• reduced body weights

homeostasis/metabolism

increased fasting circulating glucose level ( J:272522 )

• fasting hyperglycemia

hematopoietic system

increased B-1a cell number ( J:272522 )

• increased frequencies of B1a cells in the peripheral blood

decreased B cell number ( J:272522 )

• reduced frequencies of IgM+ B cells in the peripheral blood

decreased B-2 B cell number ( J:272522 )

• reduced frequencies of B2 cells in the peripheral blood

increased alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ CD4 T cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272522 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

increased macrophage cell number ( J:272522 )

• increased frequencies of macrophages in the peripheral blood

increased IgE level ( J:272522 )

• increased total IgE levels in the serum