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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vav1M4Btlr
mutation 4, Bruce Beutler
MGI:6285514
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vav1M4Btlr/Vav1M4Btlr C57BL/6J-Vav1M4Btlr MGI:6285517


Genotype
MGI:6285517
hm1
Allelic
Composition		 Vav1M4Btlr/Vav1M4Btlr
Genetic
Background		 C57BL/6J-Vav1M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1M4Btlr mutation (0 available); any Vav1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood CD4 T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood CD8 T cells
decreased B-1 B cell number ( J:272528 )
• reduced frequencies of B1 cells in the peripheral blood
increased central memory CD4-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272528 )
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:272528 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood CD4 T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272528 )
• increased expression of CD44 on peripheral blood CD8 T cells
decreased B-1 B cell number ( J:272528 )
• reduced frequencies of B1 cells in the peripheral blood
increased central memory CD4-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:272528 )
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:272528 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:272528 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory