Phenotypes associated with this allele

• Allele Symbol: Kirrel2^{tm2b(KOMP)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6285518
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kirrel2^tm2b(KOMP)Wtsi/Kirrel2^tm2b(KOMP)Wtsi	involves: C57BL/6N	MGI:6287113
cx2	Kirrel2^tm2b(KOMP)Wtsi/Kirrel2^tm2b(KOMP)Wtsi Kirrel3^tm1.1Jfcl/Kirrel3^tm1.1Jfcl	involves: C57BL/6N	MGI:6287117

Genotype
MGI:6287113

hm1

• Allelic Composition: Kirrel2^{tm2b(KOMP)Wtsi}/Kirrel2^{tm2b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:272414 )

N • adult mice show normal vomeronasal tract fasciculation with no differences in the segregation of apical and basal vomeronasal sensory neuron (VSN) axons into the anterior and posterior regions of the accessory olfactory bulb (AOB)

abnormal olfactory bulb glomerular layer morphology ( J:272414 )

• adult mice show defects in glomeruli formation with significantly larger and fewer glomeruli identified in the posterior region of AOB relative to wild-type controls

• in contrast, the anterior AOB region contains well-defined glomeruli of normal size and number

Genotype
MGI:6287117

cx2

• Allelic Composition: Kirrel2^{tm2b(KOMP)Wtsi}/Kirrel2^{tm2b(KOMP)Wtsi}; Kirrel3^tm1.1Jfcl/Kirrel3^tm1.1Jfcl
• Genetic Background: involves: C57BL/6N

nervous system

nervous system phenotype ( J:272414 )

N • adult mice exhibit normal vomeronasal tract fasciculation with no differences in the segregation of apical and basal vomeronasal sensory neuron (VSN) axons in the anterior and posterior regions of the accessory olfactory bulb (AOB)

abnormal olfactory bulb glomerular layer morphology ( J:272414 )

• adult mice show severe disruption of the glomerular layer of AOB with loss of morphologically distinct glomeruli

• glomeruli in both the anterior and posterior regions of the AOB are severely disrupted and the boundaries between glomeruli are largely indistinguishable

abnormal synaptic bouton morphology ( J:272414 )

• the average size of presynaptic terminals in the glomerular layer of AOB is significantly larger than that in controls

• however, no change is observed in the average length of asymmetric or symmetric synapses

abnormal asymmetric synapse morphology ( J:272414 )

• mice show a significantly decreased number of asymmetric synapses in the glomerular layer of AOB relative to controls

• in contrast, the number of symmetric synapses (i.e. inhibitory inputs from periglomerular cells) in the AOB glomerular layer is similar to that in controls

abnormal excitatory synapse morphology ( J:272414 )

• mice show a significantly decreased number of asymmetric synapses (i.e. excitatory glutamatergic synapses of VSN axons onto mitral cell dendrites) in the glomerular layer of AOB relative to controls