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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PtprcM9Btlr
mutation 9, Bruce Beutler
MGI:6285650
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PtprcM9Btlr/PtprcM9Btlr C57BL/6J-PtprcM9Btlr MGI:6285652


Genotype
MGI:6285652
hm1
Allelic
Composition		 PtprcM9Btlr/PtprcM9Btlr
Genetic
Background		 C57BL/6J-PtprcM9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PtprcM9Btlr mutation (0 available); any Ptprc mutation (189 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte morphology ( J:272745 )
• reduced B to T cell ratios in the peripheral blood
abnormal B cell differentiation ( J:272745 )
• reduced B220 expression on peripheral blood B cells
decreased B cell number ( J:272745 )
• reduced frequencies of B cells
decreased NK cell number ( J:272745 )
• reduced frequencies of NK cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of effector memory CD4 T cells in CD4 T cell
abnormal CD8-positive, alpha beta T cell morphology ( J:272745 )
• increased frequencies of CD44+ CD8 T cells
increased CD8-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of central memory CD4 T cells in CD4 T cells

cardiovascular system
decreased systemic arterial systolic blood pressure ( J:272745 )
• reduced systolic blood pressures

hematopoietic system
abnormal lymphocyte morphology ( J:272745 )
• reduced B to T cell ratios in the peripheral blood
abnormal B cell differentiation ( J:272745 )
• reduced B220 expression on peripheral blood B cells
decreased B cell number ( J:272745 )
• reduced frequencies of B cells
decreased NK cell number ( J:272745 )
• reduced frequencies of NK cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of effector memory CD4 T cells in CD4 T cell
abnormal CD8-positive, alpha beta T cell morphology ( J:272745 )
• increased frequencies of CD44+ CD8 T cells
increased CD8-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of central memory CD4 T cells in CD4 T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory