All Phenotypes Rel<M2Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rel^M2Btlr
mutation 2, Bruce Beutler
MGI:6285776

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rel^M2Btlr/Rel^M2Btlr	C57BL/6J-Rel^M2Btlr	MGI:6285778

Allelic Composition	Rel^M2Btlr/Rel^M2Btlr
Genetic Background	C57BL/6J-Rel^M2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rel^M2Btlr mutation (0 available); any Rel mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:272778 )

• expression of CD44 was reduced on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:272778 )

• expression of CD44 was reduced on CD4+ T cells

decreased B-1 B cell number ( J:272778 )

• reduced frequencies of B1 cells in the peripheral blood

decreased alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ CD4 T cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

hematopoietic system

abnormal T cell differentiation ( J:272778 )

• expression of CD44 was reduced on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:272778 )

• expression of CD44 was reduced on CD4+ T cells

decreased B-1 B cell number ( J:272778 )

• reduced frequencies of B1 cells in the peripheral blood

decreased alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ CD4 T cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24