All Phenotypes Rel<M2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rel^M2Btlr
mutation 2, Bruce Beutler
MGI:6285776

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rel^M2Btlr/Rel^M2Btlr	C57BL/6J-Rel^M2Btlr	MGI:6285778

Allelic Composition	Rel^M2Btlr/Rel^M2Btlr
Genetic Background	C57BL/6J-Rel^M2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rel^M2Btlr mutation (0 available); any Rel mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:272778 )

• expression of CD44 was reduced on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:272778 )

• expression of CD44 was reduced on CD4+ T cells

decreased B-1 B cell number ( J:272778 )

• reduced frequencies of B1 cells in the peripheral blood

decreased alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ CD4 T cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

hematopoietic system

abnormal T cell differentiation ( J:272778 )

• expression of CD44 was reduced on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:272778 )

• expression of CD44 was reduced on CD4+ T cells

decreased B-1 B cell number ( J:272778 )

• reduced frequencies of B1 cells in the peripheral blood

decreased alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of CD44+ CD4 T cells in the peripheral blood

decreased central memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272778 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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