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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Npm1tm1Trow
targeted mutation 1, Jennifer Trowbridge
MGI:6285874
Summary 2 genotypes


Genotype
MGI:6286134
cn1
Allelic
Composition		 Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow hematopoietic cell morphology ( J:272803 )
• increase in total number of colony forming units are found in whole bone marrow cells 4 months post-tamoxifen injection
increased granulocyte monocyte progenitor cell number ( J:272803 )
• expansion of granulocyte and granulocyte-macrophage colony types are found in whole bone marrow cells 4 months post-tamoxifen injection
decreased hematopoietic stem cell number ( J:272803 )
• decrease in frequency and total number of long term hematopoietic stem cells 4 months post-tamoxifen injection
• decrease in total number of short term hematopoietic stem cells 4 months post-tamoxifen injection
abnormal bone marrow cell physiology ( J:272803 )
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 29% of animals in a 440 day period due to myeloproliferative disorder




Genotype
MGI:6286136
cn2
Allelic
Composition		 Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Trow mutation (1 available); any Dnmt3a mutation (139 available)
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:272803 )
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 100% of animals in a 440 day period
• in 33% of mice death is the result of myeloproliferative disorder (MPD)
• in 67% of mice death is the result of mixed myelodysplastic syndrome and myeloproliferative disorder (MDS/MPD)
• bone marrow cells from MDS/MPD or MPD primary transplants transplanted into sublethally irradiated secondary recipients results in 100% lethality due to acute myeloid leukemia (AML)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory