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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4m2Btlr
mutation 2, Bruce Beutler
MGI:6285944
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4m2Btlr/Mdm4m2Btlr C57BL/6J-Mdm4m2Btlr MGI:6285946


Genotype
MGI:6285946
hm1
Allelic
Composition		 Mdm4m2Btlr/Mdm4m2Btlr
Genetic
Background		 C57BL/6J-Mdm4m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4m2Btlr mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:272830 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272830 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:272830 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272830 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory