Phenotypes associated with this allele

• Allele Symbol: Il2rb^M3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:6285961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il2rb^M3Btlr/Il2rb^M3Btlr	C57BL/6J-Il2rb^M3Btlr	MGI:6285965

Genotype
MGI:6285965

hm1

• Allelic Composition: Il2rb^M3Btlr/Il2rb^M3Btlr
• Genetic Background: C57BL/6J-Il2rb^M3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK cell number ( J:272833 )

• reduced frequencies of NK cells in the peripheral blood

abnormal T cell morphology ( J:272833 )

• increased peripheral blood CD4 to CD8 T cell ratios

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272833 )

• reduced CD44 expression on peripheral blood CD8 T cells

increased CD4-positive, alpha-beta T cell number ( J:272833 )

• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272833 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:272833 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased NK T cell number ( J:272833 )

• reduced frequencies of NK T cells in the peripheral blood

increased IgM level ( J:272833 )

• increased IgM expression on peripheral blood B cells

hematopoietic system

decreased NK cell number ( J:272833 )

• reduced frequencies of NK cells in the peripheral blood

abnormal T cell morphology ( J:272833 )

• increased peripheral blood CD4 to CD8 T cell ratios

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272833 )

• reduced CD44 expression on peripheral blood CD8 T cells

increased CD4-positive, alpha-beta T cell number ( J:272833 )

• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272833 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:272833 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased NK T cell number ( J:272833 )

• reduced frequencies of NK T cells in the peripheral blood

increased IgM level ( J:272833 )

• increased IgM expression on peripheral blood B cells