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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb2M4Btlr
mutation 4, Bruce Beutler
MGI:6286053
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb2M4Btlr/Itgb2M4Btlr C57BL/6J-Itgb2M4Btlr MGI:6286058


Genotype
MGI:6286058
hm1
Allelic
Composition		 Itgb2M4Btlr/Itgb2M4Btlr
Genetic
Background		 C57BL/6J-Itgb2M4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb2M4Btlr mutation (0 available); any Itgb2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:272843 )
• increased expression of CD44 on peripheral blood T cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272843 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:272843 )
• increased expression of CD44 on peripheral blood T cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272843 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory