All Phenotypes Arid1b<em1Iha> MGI Mouse

• average body weight is lower at 10-13 weeks of age

• mice with hydrocephalus have reduced body weight relative to mutant mice without hydrocephalus

• however, mice exhibit normal body temperature

enhanced cued conditioning behavior ( J:271850 )

• in the cued test, the freezing time of mutants is increased without conditional stimulus on the day after conditioning and the tendency is maintained for 30 days

decreased exploration in new environment ( J:271850 )

• in the open field test, mice exhibit reduced exploratory behaviors, including distance traveled and vertical activity, however time spend in the center area does not differ from wild-type mice

abnormal long-term spatial reference memory ( J:271850 )

• in the Barnes maze, mutants exhibit a similar latency in reaching the target across acquisition sessions as wild-type mice, but in the probe trial 24 hours after the acquisition, mutants spend more time around the target hole than wild-type mice, suggesting normal spatial learning ability and improved memory

cognitive inflexibility ( J:271850 )

• in the Barns maze, mutants exhibit elevated perserveration, as indicated by a longer latency in reaching a target box in the opposite location during the reversal task

increased anxiety-related response ( J:271850 )

• in the elevated plus maze, mice show a lower number of entries into open and closed arms, a lower percentage of entries into open arms, spend less time in the open arms, and travel a lower total distance indicating increased anxiety-like behaviors

increased fear-related response ( J:271850 )

• exposure to intense stimuli such as electric foot shock or forced swim test induces larger locomotor responses than in wild-type mice

• in the contextual and cued fear conditioning test, mutants show less freezing during conditioning than wild-type mice, similar levels of freezing as wild-type mice in the context test, and more freezing in the altered context in the absence of a conditioned stimulus indicating an increase in fear generalization

slow extinction of fear memory ( J:271850 )

• freezing time caused by conditional stimulus in the cued test 30 days after conditioning is longer suggesting enhanced long-term fear memory

decreased startle reflex ( J:271850 )

• startle reflex responses caused by 110 dB stimuli are reduced

• however, startle responses caused by 120 dB are similar as in wild-type mice

impaired coordination ( J:271850 )

• in the rotarod test, the latency of falling off the accelerating rotating rod is lower

• in the balance beam test, mice exhibit slower movement speed, longer duration of movement, and higher number of slips when crossing wide or narrow beams

• the number of movements is higher on the narrow beam and the latency of reaching the goal is larger on the wide beam

decreased grip strength ( J:271850 )

• grip strength and the length of falling off the wire mesh in the wire hang test are lower

increased stereotypic behavior ( J:271850 )

• in the open field test, mice show stereotypic counts that possibly reflect repetitive behaviors

increased thermal nociceptive threshold ( J:271850 )

• in the hot-plate test, latency of paw responses to a nociceptive stimulus tend to be higher

abnormal social investigation ( J:271850 )

• mice exhibit altered social behavior in the home cage, showing increased contact time with each other, however, overall activity levels are normal

• however, in a novel environment, mice exhibit normal social behavior in the social interaction test and the three-chamber test

abnormal brain vasculature morphology ( J:271850 )

• mice with hydrocephalus exhibit brains with a cavity with new vascularization

abnormal brain vasculature morphology ( J:271850 )

• mice with hydrocephalus exhibit brains with a cavity with new vascularization

hydrocephaly ( J:271850 )

• 5 of 9 mice exhibit severe hydrocephalus

enlarged lateral ventricles ( J:271850 )

• mice with hydrocephalus have enlarged lateral ventricle

abnormal hippocampus pyramidal cell layer ( J:271850 )

• mice with hydrocephalus show corruption of the pyramidal cell layer of the hippocampus

decreased prepulse inhibition ( J:271850 )

• in response to a 110 dB stimulus, heterozygotes exhibit levels of prepulse inhibition (PPI) stimulus similar to wild-type littermates but at 120 dB, the PPI is lower than that of wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:271850

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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