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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Inpp5dm4Btlr
mutation 4, Bruce Beutler
MGI:6286128
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Inpp5dm4Btlr/Inpp5dm4Btlr C57BL/6J-Inpp5dm4Btlr MGI:6286130


Genotype
MGI:6286130
hm1
Allelic
Composition		 Inpp5dm4Btlr/Inpp5dm4Btlr
Genetic
Background		 C57BL/6J-Inpp5dm4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dm4Btlr mutation (0 available); any Inpp5d mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interferon-beta secretion ( J:272854 )
• increased type I interferon production in response to dsDNA
increased tumor necrosis factor secretion ( J:272854 )
• increased TNFa secretion in response to the TLR1/2 ligand Pam3CSK4 and the TLR7 ligand R848




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory