Phenotypes associated with this allele

• Allele Symbol: Inpp5d^m5Btlr
• Allele Name: mutation 5, Bruce Beutler
• Allele ID: MGI:6286237
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inpp5d^m5Btlr/Inpp5d^m5Btlr	C57BL/6J-Inpp5d^m5Btlr	MGI:6286239

Genotype
MGI:6286239

hm1

• Allelic Composition: Inpp5d^m5Btlr/Inpp5d^m5Btlr
• Genetic Background: C57BL/6J-Inpp5d^m5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte morphology ( J:272856 )

• reduced B to T cell ratios in the peripheral blood

• reduced CD4 to CD8 T cell ratios in the peripheral blood

abnormal T cell differentiation ( J:272856 )

• expression of CD44 on peripheral blood T cells was increased in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272856 )

• expression of CD44 on peripheral blood CD8+ T cells was increased

increased B-1 B cell number ( J:272856 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:272856 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

decreased NK cell number ( J:272856 )

• reduced frequencies of NK cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272856 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:272856 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272856 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272856 )

• reduced frequencies of CD8+ T cells in the peripheral blood

cardiovascular system

decreased heart rate ( J:272856 )

• reduced heart rates

growth/size/body

decreased body weight ( J:272856 )

• reduced body weights

hematopoietic system

abnormal lymphocyte morphology ( J:272856 )

• reduced B to T cell ratios in the peripheral blood

• reduced CD4 to CD8 T cell ratios in the peripheral blood

abnormal T cell differentiation ( J:272856 )

• expression of CD44 on peripheral blood T cells was increased in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272856 )

• expression of CD44 on peripheral blood CD8+ T cells was increased

increased B-1 B cell number ( J:272856 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:272856 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

decreased NK cell number ( J:272856 )

• reduced frequencies of NK cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272856 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:272856 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:272856 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272856 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272856 )

• reduced frequencies of CD8+ T cells in the peripheral blood