Analysis Tools
mortality/aging
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• life expectancy is reduced
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growth/size/body
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• lower mean body weight, with this difference increasing with age
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behavior/neurological
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• in the Y-maze test of short-term spatial memory, spontaneous alternation behavior is impaired in 5 month old mice
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• in the novel object recognition test, 5 month old mutant mice show less exploratory preference for the novel object than for the previously presented object
• in the novel object recognition test, 5 month old mutant mice exhibit similar exploratory activity around both trial objects as wild-type mice although mutants tend to explore objects for longer period than wild-type mice
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• mice exhibit motor deficits at 8.5 months of age but not at 5 months
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• mice cross their hindlimbs when lifted by the tail
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nervous system
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• mice exhibit age dependent intracellular accumulation and insolubilzation of tau by 9 months of age, indicating age-dependent tauopathy-like tau accumulation
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• 5 month old mice exhibit impaired axonal transport in the septohippocampal pathway
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cellular
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• dynamics of tau-associated microtubules are accelerated in both the cortex and hippocampus but not the cerebellum in 4 and 7 month old mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| frontotemporal dementia | DOID:9255 |
OMIM:600274 |
J:213361 | |
| tauopathy | DOID:680 | J:213361 | ||
