Phenotypes associated with this allele

• Allele Symbol: Clcn7^tm1.1Aros
• Allele Name: targeted mutation 1.1, Antonio Rossi
• Allele ID: MGI:6287464
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clcn7^tm1.1Aros/Clcn7^tm1.1Aros	involves: 129P2/OlaHsd * C57BL/6N	MGI:6466741

Genotype
MGI:6466741

hm1

• Allelic Composition: Clcn7^tm1.1Aros/Clcn7^tm1.1Aros
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:273179 )

• mice show reduced survival

growth/size/body

failure of tooth eruption ( J:273179 )

decreased body length ( J:273179 )

skeleton

failure of tooth eruption ( J:273179 )

increased bone volume ( J:273179 )

• femoral bones show an extremely high bone volume/tissue volume ratio

osteopetrosis ( J:273179 )

• bones show severe osteopetrosis

craniofacial

failure of tooth eruption ( J:273179 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant osteopetrosis 2		DOID:0110938	OMIM:166600	J:273179