All Phenotypes Zswim7<em1Mjn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zswim7^em1Mjn
endonuclease-mediated mutation 1, Maria Jasin
MGI:6287662

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zswim7^em1Mjn/Zswim7^em1Mjn	involves: C57BL/6J * CBA/J	MGI:6287689
cx2	Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:6287690
cx3	Swsap1^em1Mjn/Swsap1^em1Mjn Zswim7^em1Mjn/Zswim7^em1Mjn	involves: C57BL/6J * CBA/J	MGI:6287691

Allelic Composition	Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:268570 )

• reduced RAD51 and DMC1 focus numbers at leptonema

• crossover defects in oocytes

• however, double strand breaks form and are resected

increased ovary apoptosis ( J:268570 )

• in some ovaries

absent ovarian follicles ( J:268570 )

• at 3 days postpartum

decreased ovary weight ( J:268570 )

• 3- to 8-fold

abnormal seminiferous tubule morphology ( J:268570 )

• reduced cellularity

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

female infertility ( J:268570 )

male infertility ( J:268570 )

cellular

abnormal chromosomal synapsis ( J:268570 )

• reduced RAD51 and DMC1 focus numbers at leptonema

• crossover defects in oocytes

• however, double strand breaks form and are resected

increased ovary apoptosis ( J:268570 )

• in some ovaries

endocrine/exocrine glands

increased ovary apoptosis ( J:268570 )

• in some ovaries

absent ovarian follicles ( J:268570 )

• at 3 days postpartum

decreased ovary weight ( J:268570 )

• 3- to 8-fold

abnormal seminiferous tubule morphology ( J:268570 )

• reduced cellularity

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (54 available)
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

N	• mice exhibit normal ovary weight and follicle development

oligozoospermia ( J:268570 )

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

reduced female fertility ( J:268570 )

• reduced litter sizes

decreased litter size ( J:268570 )

• females produce reduced litters

male infertility ( J:268570 )

cellular

oligozoospermia ( J:268570 )

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

Allelic Composition	Swsap1^em1Mjn/Swsap1^em1Mjn Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Swsap1^em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased ovary weight ( J:268570 )

• 3- to 8-fold

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

female infertility ( J:268570 )

male infertility ( J:268570 )

endocrine/exocrine glands

decreased ovary weight ( J:268570 )

• 3- to 8-fold

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

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