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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Swsap1em1Mjn
endonuclease-mediated mutation 1, Maria Jasin
MGI:6287664
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Swsap1em1Mjn/Swsap1em1Mjn involves: C57BL/6J * CBA/J MGI:6287687
cx2
 		Chek2tm1Mak/Chek2tm1Mak
Swsap1em1Mjn/Swsap1em1Mjn 		involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:6287688
cx3
 		Brca2tm1Kamc/Brca2tm1Kamc
Swsap1em1Mjn/Swsap1em1Mjn 		involves: 129P2/OlaHsd * C57BL/6J * CBA/J MGI:6287693
cx4
 		Swsap1em1Mjn/Swsap1em1Mjn
Zswim7em1Mjn/Zswim7em1Mjn 		involves: C57BL/6J * CBA/J MGI:6287691


Genotype
MGI:6287687
hm1
Allelic
Composition		 Swsap1em1Mjn/Swsap1em1Mjn
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Swsap1em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:268570 )
• seminiferous tubules are devoid of post-meiotic germ cells
abnormal chromosomal synapsis ( J:268570 )
• at early zygonema with fewer in cells that survive to mid-pachynema
• reduced RAD51 and DMC1 focus numbers at leptonema
• crossover defects in oocytes
• however, double strand breaks form and are resected
arrest of male meiosis ( J:268570 )
• mid-pachynema
increased male germ cell apoptosis ( J:268570 )
• however, apoptosis levels at 7.5 days postpartum are normal
increased ovary apoptosis ( J:268570 )
• in some ovaries
absent ovarian follicles ( J:268570 )
• at 3 days postpartum
decreased ovary weight ( J:268570 )
• 3- to 8-fold
decreased testis weight ( J:268570 )
• 3- to 4-fold
• however, testis weight at 7.5 days postpartum is normal

cellular
azoospermia ( J:268570 )
• seminiferous tubules are devoid of post-meiotic germ cells
abnormal chromosome morphology ( J:268570 )
• increased end to end fusions in spermatocytes
abnormal chromosomal synapsis ( J:268570 )
• at early zygonema with fewer in cells that survive to mid-pachynema
• reduced RAD51 and DMC1 focus numbers at leptonema
• crossover defects in oocytes
• however, double strand breaks form and are resected
arrest of male meiosis ( J:268570 )
• mid-pachynema
increased male germ cell apoptosis ( J:268570 )
• however, apoptosis levels at 7.5 days postpartum are normal
increased ovary apoptosis ( J:268570 )
• in some ovaries

endocrine/exocrine glands
increased ovary apoptosis ( J:268570 )
• in some ovaries
absent ovarian follicles ( J:268570 )
• at 3 days postpartum
decreased ovary weight ( J:268570 )
• 3- to 8-fold
decreased testis weight ( J:268570 )
• 3- to 4-fold
• however, testis weight at 7.5 days postpartum is normal




Genotype
MGI:6287688
cx2
Allelic
Composition		 Chek2tm1Mak/Chek2tm1Mak
Swsap1em1Mjn/Swsap1em1Mjn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2tm1Mak mutation (1 available); any Chek2 mutation (54 available)
Swsap1em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:268570 )
N
• mice exhibit normal ovary weight and follicle development
abnormal chromosomal synapsis ( J:268570 )
• with reduced MLH1 focus numbers
abnormal seminiferous tubule morphology ( J:268570 )
• improved cellularity compared with Zswim7em1Mjn homozygotes
reduced female fertility ( J:268570 )
• reduced litter sizes
decreased litter size ( J:268570 )
• females produce reduced litters

cellular
abnormal chromosomal synapsis ( J:268570 )
• with reduced MLH1 focus numbers

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:268570 )
• improved cellularity compared with Zswim7em1Mjn homozygotes




Genotype
MGI:6287693
cx3
Allelic
Composition		 Brca2tm1Kamc/Brca2tm1Kamc
Swsap1em1Mjn/Swsap1em1Mjn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Kamc mutation (1 available); any Brca2 mutation (132 available)
Swsap1em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromosomal synapsis ( J:268570 )
• worse than in Swsap1em1Mjn homozygotes
• delayed at early zygonema, asynapsis at early pachynema
• fewer RAD51 and DMC1 foci at leptonema and early zygonema

endocrine/exocrine glands

cellular
abnormal chromosomal synapsis ( J:268570 )
• worse than in Swsap1em1Mjn homozygotes
• delayed at early zygonema, asynapsis at early pachynema
• fewer RAD51 and DMC1 foci at leptonema and early zygonema




Genotype
MGI:6287691
cx4
Allelic
Composition		 Swsap1em1Mjn/Swsap1em1Mjn
Zswim7em1Mjn/Zswim7em1Mjn
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Swsap1em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
Zswim7em1Mjn mutation (0 available); any Zswim7 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased ovary weight ( J:268570 )
• 3- to 8-fold
decreased testis weight ( J:268570 )
• 3- to 4-fold
• however, testis weight at 7.5 days postpartum is normal

endocrine/exocrine glands
decreased ovary weight ( J:268570 )
• 3- to 8-fold
decreased testis weight ( J:268570 )
• 3- to 4-fold
• however, testis weight at 7.5 days postpartum is normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory