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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2s1em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6293838
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif2s1em1(IMPC)Mbp/Eif2s1em1(IMPC)Mbp C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd MGI:6492815
ht2
 		Eif2s1em1(IMPC)Mbp/Eif2s1+ C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd MGI:6731307


Genotype
MGI:6492815
hm1
Allelic
Composition		 Eif2s1em1(IMPC)Mbp/Eif2s1em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1em1(IMPC)Mbp mutation (1 available); any Eif2s1 mutation (57 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Eif2s1em1(IMPC)Mbp/Eif2s1em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 but no embryos detected at E7.5. Blastocysts grown in vitro fail to hatch from the zona pellucida.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• early blastocysts are present in approximate Mendelian ratios at E3.5 (30% versus expected 25%, n=33); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro, blastocysts fail to hatch and are dead after 3 days in culture, never forming outgrowths




Genotype
MGI:6731307
ht2
Allelic
Composition		 Eif2s1em1(IMPC)Mbp/Eif2s1+
Genetic
Background		 C57BL/6NCrl-Eif2s1em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1em1(IMPC)Mbp mutation (1 available); any Eif2s1 mutation (57 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

integument

nervous system

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory