Analysis Tools
cardiovascular system
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• mice exhibit an upregulation of cardiac atrial natriuretic peptide and of autophagy marker proteins Map1lc3a (LC3-II) and beclin 1, and reduced protein levels of small heat shock proteins Cryab and Hspb1
• however, heart weight/body weight is similar to controls and no inclusion bodies are seen in hearts
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• fractional shortening is slightly decreased
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cellular
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• mice exhibit upregulation of autophagy marker proteins Map1lc3a (LC3-II) and beclin 1, and reduced protein levels of small heat shock proteins Cryab and Hspb1 indicating enhanced BAG3-activated autophagy system
• mice treated with chloroquine, an inhibitor of the autophagy system, show recovery of Cryab and Hspb1 protein levels and exhibit autophagosomes and autolysosome-like structures in heart ventricles which are not seen in controls
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homeostasis/metabolism
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• mice exhibit upregulation of autophagy marker proteins Map1lc3a (LC3-II) and beclin 1, and reduced protein levels of small heat shock proteins Cryab and Hspb1 indicating enhanced BAG3-activated autophagy system
• mice treated with chloroquine, an inhibitor of the autophagy system, show recovery of Cryab and Hspb1 protein levels and exhibit autophagosomes and autolysosome-like structures in heart ventricles which are not seen in controls
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muscle
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• fractional shortening is slightly decreased
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