Phenotypes associated with this allele

• Allele Symbol: Ltv1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6294725
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltv1^em1(IMPC)J/Ltv1^em1(IMPC)J	C57BL/6NJ-Ltv1^em1(IMPC)J/Mmjax	MGI:6492938
ht2	Ltv1^em1(IMPC)J/Ltv1^+	C57BL/6NJ-Ltv1^em1(IMPC)J/Mmjax	MGI:6492937

Genotype
MGI:6492938

hm1

• Allelic Composition: Ltv1^em1(IMPC)J/Ltv1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ltv1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ltv1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ltv1^em1(IMPC)J/Ltv1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5, that appear as morula, but no embryos at E7.5. Mutants grown in vitro fail to hatch from the zona pellucida, never forming blastocysts.

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• morula-like embryos are present at E3.5 (15% versus expected 25%, n=27); no homozygous embryos or excess resorption sites are observed at E7.5

Genotype
MGI:6492937

ht2

• Allelic Composition: Ltv1^em1(IMPC)J/Ltv1⁺
• Genetic Background: C57BL/6NJ-Ltv1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ltv1

hematopoietic system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - JAX

immune system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - JAX