mortality/aging
N |
• mice survive to adulthood
|
hematopoietic system
• mild
|
Allele Symbol Allele Name Allele ID |
Cdk5rap3tm1c(EUCOMM)Hmgu targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH MGI:6294784 |
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Summary |
3 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice survive to adulthood
|
• mild
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice began to die after weaning
• however, supplementation with glucose after weaning rescues come mortality
|
• defective at 1 months with disorganized tubular structures extending away from portal tracts
• however, parenchyma organization at 0.5 months is normal
|
• smaller cell area at 1 month of age
• reduced hepatocyte maturation
|
• hepatocytes exhibit perturbed endoplasmic reticulum homeostasis (increased ER stress and activated unfolded protein response) compared with control cells
|
• at 1 month of age in fasted and fed mice
|
• however, serum aspartate transaminase levels are normal
|
• from 1 week of age
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice survive to adulthood
|
N |
• mice exhibit normal liver histology
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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