Phenotypes associated with this allele

• Allele Symbol: Cdk5rap3^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6294784
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk5rap3^tm1c(EUCOMM)Hmgu/Cdk5rap3^tm1c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6295912
cn2	Cdk5rap3^tm1c(EUCOMM)Hmgu/Cdk5rap3^tm1c(EUCOMM)Hmgu Tg(Foxa3-cre)1Khk/0	involves: 129S4/SvJaeSor * C57BL/6N * DBA	MGI:6295910
cn3	Cdk5rap3^tm1c(EUCOMM)Hmgu/Cdk5rap3^tm1c(EUCOMM)Hmgu Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S4/SvJaeSor * C57BL/6N * DBA	MGI:6295913

Genotype
MGI:6295912

cn1

• Allelic Composition: Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:272566 )

N • mice survive to adulthood

hematopoietic system

abnormal hemopoiesis ( J:272566 )

• mild

Genotype
MGI:6295910

cn2

• Allelic Composition: Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu}; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * DBA

mortality/aging

premature death ( J:272566 )

• mice began to die after weaning

• however, supplementation with glucose after weaning rescues come mortality

liver/biliary system

abnormal hepatic cord morphology ( J:272566 )

• defective at 1 months with disorganized tubular structures extending away from portal tracts

• however, parenchyma organization at 0.5 months is normal

abnormal hepatocyte morphology ( J:272566 )

• smaller cell area at 1 month of age

• reduced hepatocyte maturation

small liver ( J:272566 )

decreased liver weight ( J:272566 )

liver hypoplasia ( J:272566 )

abnormal hepatocyte physiology ( J:272566 )

• hepatocytes exhibit perturbed endoplasmic reticulum homeostasis (increased ER stress and activated unfolded protein response) compared with control cells

homeostasis/metabolism

increased circulating bilirubin level ( J:272566 )

decreased fasting circulating glucose level ( J:272566 )

hypoglycemia ( J:272566 )

• at 1 month of age in fasted and fed mice

decreased circulating cholesterol level ( J:272566 )

decreased circulating triglyceride level ( J:272566 )

increased circulating alanine transaminase level ( J:272566 )

• however, serum aspartate transaminase levels are normal

growth/size/body

decreased body weight ( J:272566 )

• from 1 week of age

Genotype
MGI:6295913

cn3

• Allelic Composition: Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * DBA

mortality/aging

mortality/aging ( J:272566 )

N • mice survive to adulthood

liver/biliary system

liver/biliary system phenotype ( J:272566 )

N • mice exhibit normal liver histology