Phenotypes associated with this allele

• Allele Symbol: Abraxas1^tm1.1Bwng
• Allele Name: targeted mutation 1.1, Bin Wang
• Allele ID: MGI:6296766
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abraxas1^tm1.1Bwng/Abraxas1^tm1.1Bwng	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	MGI:6296796
ht2	Abraxas1^tm1.1Bwng/Abraxas1^+	involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N	MGI:6296797

Genotype
MGI:6296796

hm1

• Allelic Composition: Abraxas1^tm1.1Bwng/Abraxas1^tm1.1Bwng
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:269823 )

• mice die at 7 to 28 days postirradiation compared with no wild-type mice

premature death ( J:269823 )

• all mice die before 30 months of age

cellular

abnormal cell nucleus morphology ( J:269823 )

• mouse embryonic fibroblasts exhibit increased nuclear fragmentation and micronuclei compared with wild-type mice

increased cellular sensitivity to DNA damaging agents ( J:269823 )

• induced by DNA crosslinking agent mitomycin C or poly ADP ribose polymerase (PARP) inhibitor Olaparib

increased cellular sensitivity to gamma-irradiation ( J:269823 )

abnormal double-strand DNA break repair ( J:269823 )

• impaired repair following radiation induced DNA damage in mouse embryonic fibroblast with reduced sister chromatid exchanges per metaphase

spontaneous chromosome breakage ( J:269823 )

• in mouse embryonic fibroblasts

neoplasm

increased tumor incidence ( J:269823 )

• mice develop tumors as early as 8 months with a mean age of 24 months

increased lymphoma incidence ( J:269823 )

• in 7 of 11 mice with involvement in the spleen and lymph nodes including the mesenteric and cervical lymph nodes and infiltration into the liver, lung, kidney and intestine

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:269823 )

• impaired repair following radiation induced DNA damage in mouse embryonic fibroblast with reduced sister chromatid exchanges per metaphase

increased mortality induced by gamma-irradiation ( J:269823 )

• mice die at 7 to 28 days postirradiation compared with no wild-type mice

Genotype
MGI:6296797

ht2

• Allelic Composition: Abraxas1^tm1.1Bwng/Abraxas1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

mortality/aging

premature death ( J:269823 )

• nearly all mice are dead by 30 months of age

neoplasm

increased tumor incidence ( J:269823 )

• mice develop cancer including lymphoma and other types of tumors (lung, liver and other)

• mice develop tumors as early as 8 months with a mean age of 17 months

increased lymphoma incidence ( J:269823 )

• in 14 of 21 mice with involvement in the spleen and lymph nodes including the mesenteric and cervical lymph nodes and infiltration into the liver, lung, kidney and intestine

increased histiocytic sarcoma incidence ( J:269823 )

• in one mouse

increased lung adenocarcinoma incidence ( J:269823 )

• in one mouse

respiratory system

increased lung adenocarcinoma incidence ( J:269823 )

• in one mouse