Analysis Tools
mortality/aging
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• slightly fewer than expected mice are present at weaning
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cardiovascular system
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• fasted mice exhibit increased left ventricular internal diameter and volume compared with control mice
• however, mice exhibit normal cardiac phenotype under basal conditions
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• fasted mice exhibit reduced left ventricular fractional shortening and longitudinal strain rate compared with control mice
• 4 weeks after pressure overload induced by transverse aortic constriction combined with a small apical myocardial infarction (TAC/MI), mice exhibit more severe left ventricle dysfunction including lower left ventricle ejection fraction and greater left ventricle end-diastolic volume and end-systolic volume compared with control mice
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muscle
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• fasted mice exhibit reduced left ventricular fractional shortening and longitudinal strain rate compared with control mice
• 4 weeks after pressure overload induced by transverse aortic constriction combined with a small apical myocardial infarction (TAC/MI), mice exhibit more severe left ventricle dysfunction including lower left ventricle ejection fraction and greater left ventricle end-diastolic volume and end-systolic volume compared with control mice
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