Phenotypes associated with this allele

• Allele Symbol: Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Allele Name: transposon insertion 1.1, Yuan Zhuang
• Allele ID: MGI:6303587
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/N-Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:6303603
hm2	Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/NJ-Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425026
hm3	Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	involves: C57BL/6J * FVB/NJ	MGI:7425032
ht4	Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^+	FVB/N-Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:6303604
cx5	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425028
cx6	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^+	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425029
cx7	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^+ Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	FVB/NJ-Eme1^Tn(pb-Act-RFP)1.1Zhu Gen1^Tn(pb-Act-RFP)1.1Zhu	MGI:7425030
cx8	Eme1^Tn(pb-Act-RFP)1.1Zhu/Eme1^+ Gen1^Tn(pb-Act-RFP)1.1Zhu/Gen1^Tn(pb-Act-RFP)1.1Zhu	involves: C57BL/6J * FVB/NJ	MGI:7425031

Genotype
MGI:6303603

hm1

• Allelic Composition: Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/N-Gen1^{Tn(pb-Act-RFP)1.1Zhu}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

hydronephrosis ( J:272082 )

• unilateral in 8 of 60 mice

duplex kidney ( J:272082 )

• 15 of 60 mice have unilateral duplex kidneys

• 1 in 60 mice have bilateral duplex kidney

• duplex kidneys are bipapillary

single kidney ( J:272082 )

• 11 of 60 mice exhibit unilateral renal agenesis

abnormal ureteric bud morphology ( J:272082 )

• some mice develop single ureteric bud in a more anterior position to the end of the nephric duct on one or both side unlike wild-type mice

impaired branching involved in ureteric bud morphogenesis ( J:272082 )

• in 11 of 47 ureteric buds at E11.5

ectopic ureteric bud ( J:272082 )

• on one side in 9 of 11 mice at E11.0

vesicoureteral reflux ( J:272082 )

nervous system

delayed neural tube closure ( J:272082 )

limbs/digits/tail

kinked tail ( J:272082 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:272082 )

N • mice exhibit normal blood urea nitrogen and creatinine concentration in the serum

embryo

delayed neural tube closure ( J:272082 )

Genotype
MGI:7425026

hm2

• Allelic Composition: Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/NJ-Gen1^{Tn(pb-Act-RFP)1.1Zhu}

cellular

cellular phenotype ( J:330453 )

N • mouse embryonic fibroblasts exhibit normal survival rates in response to treatment with DNA damaging agents

Genotype
MGI:7425032

hm3

• Allelic Composition: Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: involves: C57BL/6J * FVB/NJ

cellular

cellular phenotype ( J:330453 )

N • normal meiotic recombination efficiency

Genotype
MGI:6303604

ht4

• Allelic Composition: Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1⁺
• Genetic Background: FVB/N-Gen1^{Tn(pb-Act-RFP)1.1Zhu}

renal/urinary system

duplex kidney ( J:272082 )

• unilateral in 11 of 49 newborns

impaired branching involved in ureteric bud morphogenesis ( J:272082 )

• in on of 7 mice with unilateral ectopic ureteric buds at E11.5

ectopic ureteric bud ( J:272082 )

• on one side in 1 of 21 mice at E11.0

Genotype
MGI:7425028

cx5

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu}; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:330453 )

• no mice are present at E3.5

Genotype
MGI:7425029

cx6

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1^{Tn(pb-Act-RFP)1.1Zhu}; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1⁺
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

mortality/aging

prenatal lethality, complete penetrance ( J:330453 )

• no mice are born

Genotype
MGI:7425030

cx7

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: FVB/NJ-Eme1^{Tn(pb-Act-RFP)1.1Zhu} Gen1^{Tn(pb-Act-RFP)1.1Zhu}

cellular

increased cellular sensitivity to DNA damaging agents ( J:330453 )

• in mouse embryonic fibroblasts treated with camptothecin or etoposidecompared with cells from Eme1^{Tn(pb-Act-RFP)1.1Zhu} heterozygotes

• however, cells treated with mitomycin C, methyl methanesulfonate, or hydroxy- urea exhibit normal survival

Genotype
MGI:7425031

cx8

• Allelic Composition: Eme1^{Tn(pb-Act-RFP)1.1Zhu}/Eme1⁺; Gen1^{Tn(pb-Act-RFP)1.1Zhu}/Gen1^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: involves: C57BL/6J * FVB/NJ

cellular

abnormal cell physiology ( J:330453 )

reproductive system

reproductive system phenotype ( J:330453 )

N • mice exhibit normal testes and fertility