Phenotypes associated with this allele

• Allele Symbol: Lmbr1l^em1Btlr
• Allele Name: endonuclease-mediated mutation 1, Bruce Beutler
• Allele ID: MGI:6303829
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmbr1l^em1Btlr/Lmbr1l^em1Btlr	C57BL/6J-Lmbr1l^em1Btlr	MGI:6303872

Genotype
MGI:6303872

hm1

• Allelic Composition: Lmbr1l^em1Btlr/Lmbr1l^em1Btlr
• Genetic Background: C57BL/6J-Lmbr1l^em1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased leukocyte cell number ( J:274568 )

decreased monocyte cell number ( J:274568 )

abnormal lymphocyte morphology ( J:274568 )

• B cell to T cell ratio is increased

abnormal B cell differentiation ( J:274568 )

decreased lymphocyte cell number ( J:274568 )

decreased T cell number ( J:274568 )

• T cell deficiency is not rescued by Tnf, Fas or Casp3 deficiencies

decreased CD4-positive, alpha-beta T cell number ( J:274568 )

• decreased frequency of CD3+ T cells in peripheral blood

abnormal alpha-beta T cell morphology ( J:274568 )

• increased CD4+ to CD8+ T cell ratio

decreased IgD level ( J:274568 )

• surface expression

decreased IgG level ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

decreased IgM level ( J:274568 )

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

increased IgM level ( J:274568 )

• surface expression

impaired natural killer cell mediated cytotoxicity ( J:274568 )

abnormal cytotoxic T cell physiology ( J:274568 )

impaired humoral immune response ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

hematopoietic system

abnormal bone marrow cell morphology/development ( J:274568 )

• decreased lymphoid-primed multipotent progenitors

• increased multipotent progenitors

• however, bone marrow contain normal numbers of common myeloid progenitors (CMPs), megakaryocyte-erythrocyte progenitors (MEPs) and granulocyte-macrophage progenitors (GMPs)

decreased common lymphocyte progenitor cell number ( J:274568 )

decreased leukocyte cell number ( J:274568 )

decreased monocyte cell number ( J:274568 )

increased hematopoietic cell number ( J:274568 )

• increased LSK+ cells, long-term HSC and short-term HSC

• however, bone marrow contain normal numbers of LK+ cells

abnormal lymphocyte morphology ( J:274568 )

• B cell to T cell ratio is increased

abnormal B cell differentiation ( J:274568 )

decreased lymphocyte cell number ( J:274568 )

decreased T cell number ( J:274568 )

• T cell deficiency is not rescued by Tnf, Fas or Casp3 deficiencies

decreased CD4-positive, alpha-beta T cell number ( J:274568 )

• decreased frequency of CD3+ T cells in peripheral blood

abnormal alpha-beta T cell morphology ( J:274568 )

• increased CD4+ to CD8+ T cell ratio

decreased IgD level ( J:274568 )

• surface expression

decreased IgG level ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

decreased IgM level ( J:274568 )

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

increased IgM level ( J:274568 )

• surface expression

impaired natural killer cell mediated cytotoxicity ( J:274568 )

abnormal cytotoxic T cell physiology ( J:274568 )