Analysis Tools
skeleton
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• mice exhibit increased susceptibility to collagen-induced arthritis (CIA), showing higher clinical scores and incidence of CIA
• arthritic joints of CIA mice show higher levels of infiltration of polymorphonuclear leukocytes, pannus formation, erosion of cartilage, and bone destruction
• mice with CIA show upregulation of Il6, Cxcl2, Nos2, and Il1b mRNA expression in inflammatory joints, indicating enhanced inflammatory mediator production
• however, anti-chicken type II collagen (IIC) antibody concentrations in the serum, IIC-specific T cell proliferative responses and cytokine production in lymph node cells upon stimulation with IIC are normal, indicating normal T cell priming and production of antigen-specific antibodies
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immune system
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• mice show no obvious phenotypic abnormalities under specific pathogen-free conditions and the content of T cells, B cells, plasmacytoid dendritic cells (DCs), conventional DCs, migratory DCs, monocytes, and neutrophils in the lymph nodes and bone marrow are normal
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• bone marrow macrophages and TGCMPs show enhanced mRNA expression of Il1a, Il1b, Cxcl2, Nos2, and Ptgs
• however, neutrophils show normal phenotype
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• bone marrow macrophages and thioglycolate-elicited peritoneal macrophages (TGCMPs) show higher TNF and IL-6 production in response to stimulation with IL-1alpha or IL-1beta but not LPS
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• mice exhibit increased susceptibility to collagen-induced arthritis (CIA), showing higher clinical scores and incidence of CIA
• arthritic joints of CIA mice show higher levels of infiltration of polymorphonuclear leukocytes, pannus formation, erosion of cartilage, and bone destruction
• mice with CIA show upregulation of Il6, Cxcl2, Nos2, and Il1b mRNA expression in inflammatory joints, indicating enhanced inflammatory mediator production
• however, anti-chicken type II collagen (IIC) antibody concentrations in the serum, IIC-specific T cell proliferative responses and cytokine production in lymph node cells upon stimulation with IIC are normal, indicating normal T cell priming and production of antigen-specific antibodies
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hematopoietic system
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• bone marrow macrophages and TGCMPs show enhanced mRNA expression of Il1a, Il1b, Cxcl2, Nos2, and Ptgs
• however, neutrophils show normal phenotype
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• bone marrow macrophages and thioglycolate-elicited peritoneal macrophages (TGCMPs) show higher TNF and IL-6 production in response to stimulation with IL-1alpha or IL-1beta but not LPS
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