Phenotypes associated with this allele

• Allele Symbol: Ltn1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6304241
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltn1^tm1b(EUCOMM)Hmgu/Ltn1^tm1b(EUCOMM)Hmgu	C57BL/6N-Ltn1^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6480500
ht2	Ltn1^tm1b(EUCOMM)Hmgu/Ltn1^+	C57BL/6N-Ltn1^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6492936

Genotype
MGI:6480500

hm1

• Allelic Composition: Ltn1^{tm1b(EUCOMM)Hmgu}/Ltn1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ltn1^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0658_5_C10

Data Sources

IMPC Data for Ltn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - CCP-IMG

growth/size/body

decreased body weight ( J:211773 )

♀

IMPC - CCP-IMG

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♀

IMPC - CCP-IMG

thrombocytopenia ( J:211773 )

♀

IMPC - CCP-IMG

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

♀

IMPC - CCP-IMG

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - CCP-IMG

immune system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

♀

IMPC - CCP-IMG

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - CCP-IMG

respiratory system

increased lung elastance ( J:211773 )

♀

IMPC - CCP-IMG

increased lung tissue damping ( J:211773 )

♀

IMPC - CCP-IMG

increased airway resistance ( J:211773 )

♀

IMPC - CCP-IMG

vision/eye

abnormal cornea morphology ( J:211773 )

♀

IMPC - CCP-IMG

Genotype
MGI:6492936

ht2

• Allelic Composition: Ltn1^{tm1b(EUCOMM)Hmgu}/Ltn1⁺
• Genetic Background: C57BL/6N-Ltn1^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0658_5_C10

Data Sources

IMPC Data for Ltn1

behavior/neurological

increased freezing behavior ( J:211773 )

♀

IMPC - CCP-IMG