Phenotypes associated with this allele

• Allele Symbol: Themis^m5Btlr
• Allele Name: mutation 5, Bruce Beutler
• Allele ID: MGI:6304287
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Themis^m5Btlr/Themis^m5Btlr	C57BL/6J-Themis^m5Btlr	MGI:6304289

Genotype
MGI:6304289

hm1

• Allelic Composition: Themis^m5Btlr/Themis^m5Btlr
• Genetic Background: C57BL/6J-Themis^m5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood CD8+ T cells

increased central memory CD4-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:274716 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274716 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased NK T cell number ( J:274716 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:274716 )

• increased peripheral blood B to T cell ratios

• reduced peripheral blood CD4 to CD8 T cell ratios

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274716 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274716 )

• reduced frequencies of CD8+ T cells in the peripheral blood

immune system

abnormal T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274716 )

• expression of CD44 was increased on peripheral blood CD8+ T cells

increased central memory CD4-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta memory T cell number ( J:274716 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274716 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274716 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased NK T cell number ( J:274716 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:274716 )

• increased peripheral blood B to T cell ratios

• reduced peripheral blood CD4 to CD8 T cell ratios

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274716 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274716 )

• reduced frequencies of CD8+ T cells in the peripheral blood