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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkdcm18Btlr
mutation 18, Bruce Beutler
MGI:6304295
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkdcm18Btlr/Prkdcm18Btlr C57BL/6J-Prkdcm18Btlr MGI:6304297


Genotype
MGI:6304297
hm1
Allelic
Composition		 Prkdcm18Btlr/Prkdcm18Btlr
Genetic
Background		 C57BL/6J-Prkdcm18Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcm18Btlr mutation (0 available); any Prkdc mutation (417 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:274730 )
• reduced B220 expression on peripheral blood B cells
abnormal T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD4+ T cells
abnormal CD4-positive T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD4+ T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD8+ T cells
• reduced peripheral blood CD4 to CD8 T cell ratios
decreased B cell number ( J:274730 )
• reduced frequencies of B cells in the peripheral blood
• reduced peripheral blood B to T cell ratios
decreased B-1 B cell number ( J:274730 )
• reduced frequencies of B1 cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274730 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
decreased alpha-beta T cell number ( J:274730 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274730 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274730 )
• reduced frequencies of CD8+ T cells in the peripheral blood
increased T cell number ( J:274730 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of CD44+ CD4 T cells in the peripheral blood
increased central memory CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of CD44+ CD8 T cells and CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system
abnormal B cell differentiation ( J:274730 )
• reduced B220 expression on peripheral blood B cells
abnormal T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD4+ T cells
abnormal CD4-positive T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD4+ T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274730 )
• increased expression of CD44 on peripheral blood CD8+ T cells
• reduced peripheral blood CD4 to CD8 T cell ratios
decreased B cell number ( J:274730 )
• reduced frequencies of B cells in the peripheral blood
• reduced peripheral blood B to T cell ratios
decreased B-1 B cell number ( J:274730 )
• reduced frequencies of B1 cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274730 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
decreased alpha-beta T cell number ( J:274730 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274730 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274730 )
• reduced frequencies of CD8+ T cells in the peripheral blood
increased T cell number ( J:274730 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of CD44+ CD4 T cells in the peripheral blood
increased central memory CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of CD44+ CD8 T cells and CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274730 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory