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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc5m1Btlr
mutation 1, Bruce Beutler
MGI:6304305
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xrcc5m1Btlr/Xrcc5m1Btlr C57BL/6J-Xrcc5m1Btlr MGI:6304307


Genotype
MGI:6304307
hm1
Allelic
Composition		 Xrcc5m1Btlr/Xrcc5m1Btlr
Genetic
Background		 C57BL/6J-Xrcc5m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5m1Btlr mutation (0 available); any Xrcc5 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:274736 )
• increased B220 on peripheral blood B cells
abnormal T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood CD8+ T cells
increased neutrophil cell number ( J:274736 )
• increased frequencies of neutrophils in the peripheral blood
increased dendritic cell number ( J:274736 )
• increased frequencies of CD11c+ DCs in the peripheral blood
decreased B-2 B cell number ( J:274736 )
• reduced frequencies of B2 cells in the peripheral blood
increased B-1a cell number ( J:274736 )
• increased frequencies of B1a cells in the peripheral blood
increased B-1b cell number ( J:274736 )
• increased frequencies of B1b cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274736 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood
decreased T cell number ( J:274736 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD4+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
abnormal B cell differentiation ( J:274736 )
• increased B220 on peripheral blood B cells
abnormal T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood CD8+ T cells
increased neutrophil cell number ( J:274736 )
• increased frequencies of neutrophils in the peripheral blood
increased dendritic cell number ( J:274736 )
• increased frequencies of CD11c+ DCs in the peripheral blood
decreased B-2 B cell number ( J:274736 )
• reduced frequencies of B2 cells in the peripheral blood
increased B-1a cell number ( J:274736 )
• increased frequencies of B1a cells in the peripheral blood
increased B-1b cell number ( J:274736 )
• increased frequencies of B1b cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274736 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood
decreased T cell number ( J:274736 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD4+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory