All Phenotypes Cd8b1<m2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd8b1^m2Btlr
mutation 2, Bruce Beutler
MGI:6304443

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd8b1^m2Btlr/Cd8b1^m2Btlr	C57BL/6J-Cd8b1^m2Btlr	MGI:6304445

Allelic Composition	Cd8b1^m2Btlr/Cd8b1^m2Btlr
Genetic Background	C57BL/6J-Cd8b1^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8b1^m2Btlr mutation (0 available); any Cd8b1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:274761 )

• expression of B220 on peripheral B cells was reduced

• increase in the peripheral blood B to T cell ratio

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274761 )

• the expression of CD44 on CD8+T cells was increased

• increase in the peripheral blood CD4+to CD8+T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of CD4+T cells and CD4+T cells in CD3+T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274761 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274761 )

• reduced frequencies of T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274761 )

• reduced frequencies of CD8+T cells, CD8+T cells in CD3+T cells, and CD44+CD8 T cells in the peripheral blood

hematopoietic system

abnormal B cell differentiation ( J:274761 )

• expression of B220 on peripheral B cells was reduced

• increase in the peripheral blood B to T cell ratio

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274761 )

• the expression of CD44 on CD8+T cells was increased

• increase in the peripheral blood CD4+to CD8+T cell ratio

increased CD4-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of CD4+T cells and CD4+T cells in CD3+T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274761 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274761 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274761 )

• reduced frequencies of T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274761 )

• reduced frequencies of CD8+T cells, CD8+T cells in CD3+T cells, and CD44+CD8 T cells in the peripheral blood

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