Phenotypes associated with this allele

• Allele Symbol: Prkdc^m19Btlr
• Allele Name: mutation 19, Bruce Beutler
• Allele ID: MGI:6304458
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^m19Btlr/Prkdc^m19Btlr	C57BL/6J-Prkdc^m19Btlr	MGI:6304914

Genotype
MGI:6304914

hm1

• Allelic Composition: Prkdc^m19Btlr/Prkdc^m19Btlr
• Genetic Background: C57BL/6J-Prkdc^m19Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:274763 )

• reduced B220 expression on peripheral blood B cells

• increased peripheral blood B to T cell ratios

abnormal T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood CD4+ T cells

• increased peripheral blood CD4 to CD8 T cell ratios

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood CD8+ T cells

decreased B cell number ( J:274763 )

• reduced frequencies of B cells in the peripheral blood

decreased B-1 B cell number ( J:274763 )

• reduced frequencies of B1 cells in the peripheral blood

increased NK cell number ( J:274763 )

• increased frequencies of NK cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274763 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274763 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274763 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274763 )

• reduced frequencies of CD8+ T cells in the peripheral blood

hematopoietic system

abnormal B cell differentiation ( J:274763 )

• reduced B220 expression on peripheral blood B cells

• increased peripheral blood B to T cell ratios

abnormal T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood CD4+ T cells

• increased peripheral blood CD4 to CD8 T cell ratios

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274763 )

• expression of CD44 was increased on peripheral blood CD8+ T cells

decreased B cell number ( J:274763 )

• reduced frequencies of B cells in the peripheral blood

decreased B-1 B cell number ( J:274763 )

• reduced frequencies of B1 cells in the peripheral blood

increased NK cell number ( J:274763 )

• increased frequencies of NK cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:274763 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274763 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274763 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274763 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274763 )

• reduced frequencies of CD8+ T cells in the peripheral blood