Phenotypes associated with this allele

• Allele Symbol: Prkcb^M4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:6305123
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkcb^M4Btlr/Prkcb^M4Btlr	C57BL/6J-Prkcb^M4Btlr	MGI:6305125

Genotype
MGI:6305125

hm1

• Allelic Composition: Prkcb^M4Btlr/Prkcb^M4Btlr
• Genetic Background: C57BL/6J-Prkcb^M4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1 B cell number ( J:274860 )

• reduced frequencies of B1 cells in the peripheral blood

increased T cell number ( J:274860 )

• increased frequencies of T cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

increased CD4-positive, alpha-beta T cell number ( J:274860 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274860 )

• increased frequencies of CD8+ T cells in the peripheral blood

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system

decreased B-1 B cell number ( J:274860 )

• reduced frequencies of B1 cells in the peripheral blood

increased T cell number ( J:274860 )

• increased frequencies of T cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

increased CD4-positive, alpha-beta T cell number ( J:274860 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274860 )

• increased frequencies of CD8+ T cells in the peripheral blood

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood