All Phenotypes Irf8<m2Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf8^m2Btlr
mutation 2, Bruce Beutler
MGI:6305310

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf8^m2Btlr/Irf8^m2Btlr	C57BL/6J-Irf8^m2Btlr	MGI:6305315

Allelic Composition	Irf8^m2Btlr/Irf8^m2Btlr
Genetic Background	C57BL/6J-Irf8^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^m2Btlr mutation (0 available); any Irf8 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

• increased peripheral blood CD4+ to CD8+ T cell ratio

hematopoietic system

• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

• increased peripheral blood CD4+ to CD8+ T cell ratio

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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