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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat1m5Btlr
mutation 1, Bruce Beutler
MGI:6305319
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat1m5Btlr/Stat1m5Btlr C57BL/6J-Stat1m5Btlr MGI:6305323


Genotype
MGI:6305323
hm1
Allelic
Composition		 Stat1m5Btlr/Stat1m5Btlr
Genetic
Background		 C57BL/6J-Stat1m5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1m5Btlr mutation (0 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood CD4 T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood CD8 T cells
decreased CD8-positive, naive alpha-beta T cell number ( J:274938 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased T cell number ( J:274938 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of CD44+ CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased cytotoxic T cell cytolysis ( J:274938 )
• decreased killing of CTL targets pulsed with a MHC-class I restrictedpeptide for beta-galactosidase after immunization with rSFV-beta-galactosidase

hematopoietic system
abnormal T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood CD4 T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274938 )
• increased CD44 expression on peripheral blood CD8 T cells
decreased CD8-positive, naive alpha-beta T cell number ( J:274938 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased T cell number ( J:274938 )
• increased frequencies of CD44+ T cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of CD44+ CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274938 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased cytotoxic T cell cytolysis ( J:274938 )
• decreased killing of CTL targets pulsed with a MHC-class I restrictedpeptide for beta-galactosidase after immunization with rSFV-beta-galactosidase




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory