Phenotypes associated with this allele

• Allele Symbol: Jak3^m8Btlr
• Allele Name: mutation 8, Bruce Beutler
• Allele ID: MGI:6305331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^m8Btlr/Jak3^m8Btlr	C57BL/6J-Jak3^m8Btlr	MGI:6305342

Genotype
MGI:6305342

hm1

• Allelic Composition: Jak3^m8Btlr/Jak3^m8Btlr
• Genetic Background: C57BL/6J-Jak3^m8Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased dendritic cell number ( J:274939 )

• reduced frequencies of CD11b+ DCs (gated in CD11c+ cells) in the peripheral blood

increased B-1b cell number ( J:274939 )

• increased frequencies of B1b cells in the peripheral blood

decreased B cell number ( J:274939 )

• reduced frequencies of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:274939 )

• reduced frequencies of B1 cells in the peripheral blood

decreased B-2 B cell number ( J:274939 )

• reduced frequencies of B2 cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274939 )

• increased frequencies of effector memory CD4 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274939 )

• reduced frequencies of naive CD8 T cells in the peripheral blood

decreased T cell number ( J:274939 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274939 )

• reduced frequencies of CD4+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274939 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased IgG level ( J:274939 )

• diminished T-dependent antibody response to ovalbumin (OVA) administered with aluminum hydroxide and to rSFV-Beta-gal

decreased IgM level ( J:274939 )

• diminished T-independent antibody response to TNP-Ficoll

impaired humoral immune response ( J:274939 )

• diminished T-dependent antibody response to ovalbumin (OVA) administered with aluminum hydroxide and to rSFV-Beta-gal

• diminished T-independent antibody response to TNP-Ficoll

decreased response to antigen ( J:274939 )

• diminished T-dependent antibody response to ovalbumin (OVA) administered with aluminum hydroxide and to rSFV-Beta-gal

• diminished T-independent antibody response to TNP-Ficoll

hematopoietic system

decreased dendritic cell number ( J:274939 )

• reduced frequencies of CD11b+ DCs (gated in CD11c+ cells) in the peripheral blood

increased B-1b cell number ( J:274939 )

• increased frequencies of B1b cells in the peripheral blood

decreased B cell number ( J:274939 )

• reduced frequencies of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:274939 )

• reduced frequencies of B1 cells in the peripheral blood

decreased B-2 B cell number ( J:274939 )

• reduced frequencies of B2 cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274939 )

• increased frequencies of effector memory CD4 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274939 )

• reduced frequencies of naive CD8 T cells in the peripheral blood

decreased T cell number ( J:274939 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274939 )

• reduced frequencies of CD4+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274939 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased IgG level ( J:274939 )

• diminished T-dependent antibody response to ovalbumin (OVA) administered with aluminum hydroxide and to rSFV-Beta-gal

decreased IgM level ( J:274939 )

• diminished T-independent antibody response to TNP-Ficoll