Phenotypes associated with this allele

• Allele Symbol: Ptprc^m12Btlr
• Allele Name: mutation 12, Bruce Beutler
• Allele ID: MGI:6305858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^m12Btlr/Ptprc^m12Btlr	C57BL/6J-Ptprc^m12Btlr	MGI:6305860

Genotype
MGI:6305860

hm1

• Allelic Composition: Ptprc^m12Btlr/Ptprc^m12Btlr
• Genetic Background: C57BL/6J-Ptprc^m12Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1 B cell number ( J:274972 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274972 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274972 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274972 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system

increased B-1 B cell number ( J:274972 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274972 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274972 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274972 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood