Phenotypes associated with this allele

• Allele Symbol: Tg(HBB*)L2Pai
• Allele Name: transgene insertion L2, Panayiotis A Ioannou
• Allele ID: MGI:6306307
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hbb-b1^tm1Unc/Hbb-b1^+ Hbb-b2^tm1Unc/Hbb-b2^+ Tg(HBB*)L2Pai/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6306309
cx2	Hbb-b1^tm1Unc/Hbb-b1^tm1Unc Hbb-b2^tm1Unc/Hbb-b2^tm1Unc Tg(HBB*)L2Pai/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6306310

Genotype
MGI:6306309

cx1

• Allelic Composition: Hbb-b1^tm1Unc/Hbb-b1⁺; Hbb-b2^tm1Unc/Hbb-b2⁺; Tg(HBB*)L2Pai/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:97548 )

abnormal erythropoiesis ( J:97548 )

• active but ineffective erythropoiesis and hemolysis

decreased erythrocyte cell number ( J:97548 )

decreased hematocrit ( J:97548 )

decreased hemoglobin content ( J:97548 )

decreased mean corpuscular volume ( J:97548 )

increased red blood cell distribution width ( J:97548 )

anisocytosis ( J:97548 )

poikilocytosis ( J:97548 )

reticulocytosis ( J:97548 )

homeostasis/metabolism

increased circulating bilirubin level ( J:97548 )

immune system

enlarged spleen ( J:97548 )

growth/size/body

enlarged spleen ( J:97548 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:97548

Genotype
MGI:6306310

cx2

• Allelic Composition: Hbb-b1^tm1Unc/Hbb-b1^tm1Unc; Hbb-b2^tm1Unc/Hbb-b2^tm1Unc; Tg(HBB*)L2Pai/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:97548 )

• embryos survive until late in pregnancy (E18) but no live pups are seen

growth/size/body

decreased fetal size ( J:97548 )

hematopoietic system

anemia ( J:97548 )