Analysis Tools
homeostasis/metabolism
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• 2.5-fold increase in FGF21 serum levels under fasting and refeeding conditions
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• when fed a high-fat diet with improved hyperglycemia, hyperlipidemia, and hyperinsulinemia
• however, expression of the wild-type protein reverses this phenotype whereas an E239A mutant does not
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• improved hyperglycemia when fed a high-fat diet compared with wild-type mice
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• improved hyperinsulinemia when fed a high-fat diet compared with wild-type mice
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• in mice fed a high-fat diet
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• improved hyperlipidemia when fed a high-fat diet compared with wild-type mice
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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adipose tissue
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• in mice fed a high-fat diet with less fat accumulation and smaller adipocytes
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• in mice fed a high-fat diet
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• subcutaneous and epididymal in mice fed a high-fat diet
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• in mice fed a high-fat diet
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growth/size/body
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• in mice fed a high-fat diet
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• when fed a high-fat diet with improved hyperglycemia, hyperlipidemia, and hyperinsulinemia
• however, expression of the wild-type protein reverses this phenotype whereas an E239A mutant does not
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liver/biliary system
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• in mice fed a high-fat diet
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• mice fed a high-fat diet exhibit smaller livers with smaller lipid droplets and lower hepatic triglyceride accumulation compared with wild-type mice
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behavior/neurological
| N |
• mice fed a high fat diet exhibit normal food intake and locomotor activity
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skeleton
| N |
• mice exhibit normal bone homeostasis
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integument
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• in mice fed a high-fat diet
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